Animal model holds the key to understanding bipolar disorder

Bipolar Disorder (BPD or manic-depressive illness) is one of the most serious of all mental disorders, affecting millions of individuals worldwide. Affected individuals alternate between states of deep depression and mania. Now, a mouse model of the disease has been developed. Researchers found that the glutamate receptor 6 (GluR6) gene is associated with bipolar disorder. Mice that were missing the GluR6 gene underwent a series of tests designed to approximate the symptoms of mania. These mice showed many of the symptoms of mania, including hyperactivity, aggressiveness, driven or increased goal-directed pursuits, risk-taking, and super-sensitivity to amphetamine. The researchers also found that treating the mice with lithium -- the classic treatment for bipolar disorder -- reduced these symptoms. ... > read full article